The changes of lipid peroxidation during the renal ischemic and ischemic/reperfusion injury of the rat kidney
- VernacularTitle:脂质过氧化在肾缺血和缺血/再灌注损伤中的变化
- Author:
Jingping OUYANG
;
Hong LING
- Publication Type:Journal Article
- Keywords:
Lipid peroxides;
Kidney;
Rats;
Xanthine oxidase
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The changes of lipid peroxidation in the ischemic (renal artery occlusion for 75 min) and ischemie/reperfusion (renal artery occlusion 60 min plus 15 min reflow) kidney was studied in 19 male SD rats. The results showed that malondialdehydc of renal cortex and medulla was increased, but in both groups SOD and GSH-Px were not changed significantly. Activity of xanthine oxidase activity in the ischemic/reperfusion kidney were increased as compared with normal. These results suggest that lipid pcroxidation was involved in the ischemic and ischemic/reperfusion renal injury, and xanthine-xanthine oxidase might be one of the major sources of oxygen free radical when oxygen supply to ischemic kidney was restored.
