The effects of sodium selenite on the AOH-induced DNA single strand breaks and lipid peroxidation
- VernacularTitle:亚硒酸钠对交链孢酚诱发DNA单链断裂和脂质过氧化的影响
- Author:
Qingmei JIA
;
Guiting LIU
- Publication Type:Journal Article
- Keywords:
Selenium;
Esophageal neoplasms;
Alternaria;
Mycotoxins;
DNA;
Lipid peroxides
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The alkaline elution and flurometric DNA assay for the mesurement of the DNA single-strand breaks (SSB) and the thiobarbituric, acid test for the mesurement of molondialdehyde (MDA) were adopted in this article to study the effects of sodium selenite (Na_2SeO_3) on the mutagenicity of AOH. The results showed that pretreating the cells or epithelia with 10~(-5) or 10~(-6)M Na_2SeO_3 for 4 hours prior to exposure to AOH could inhibit the AOH-induced DNA SSB and the content of MDA which was the terminal pro duct of the lipid peroxidation (comparing with the control group, P
