A study on status of the immunity in alloxan diabetic mice and the immunoregulation of insulin
- VernacularTitle:四氧嘧啶糖尿病小鼠免疫状态及胰岛素免疫调节作用的研究
- Author:
Xun QU
;
Zhengyan CUI
- Publication Type:Journal Article
- Keywords:
Diabetes;
Insulin;
Lymphocytes;
Mitogenic factors, lymphocyte
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
This paper report the effects of hyperglucosemia and hypoinsulinemia on Immune system of alloxan diabetic mice. The results showed that the weight of thymus and spleen as well as the YAC-1 cell cleaning rate in the organs (lung, liver, blood) of the diabetic mice were significantly lower than that of the control. The proliferation response to Con A(2.5-20?g/ml) and the production of IL-2 of the lymphocytes were inhibi-ted markedly. When the lymphocytes were suspended in the culture medium containiny insulin, the proliferation response and the production of IL-2 increased markedly. These results suggested that the functions of lymphocytes and their natural killer activity were impaired in diabetic mice. Insulin is one of the important immunoregulation hormones and plays an important role in the regulation of immune system.
