Changes of surfactant phospholipids in acute alveolar injury of the rats
- VernacularTitle:大鼠肺表面活性物质磷脂在急性肺泡损伤时的变化
- Author:
Guohui FU
- Publication Type:Journal Article
- Keywords:
Pulmonary surfactant;
Phospholipids;
Lung;
Injuries
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Acute alveolar injury was induced in rats by subcutaneous injection of Nnitroso-N-methylurethane (NMU) 6mg/kg body wt. NMU decreased the content of surfactent phosphoLipids, and increased the protein of alveolar lavage return of rats after 2 days of the injection. Such changes were not observed in lamellar bodies and microsomcs. Composition of phospholipids also changed in all lung fractions it showed that the ratio of PG/PI was decreased significantly in response to NMU. The molecular species profiles of both acidic phospholipids in the lung fractions were distinctly different from each other and the main molecular species were attered during the acute alveolar injury.
