Effect of dietary oils on pulmonary vascular reactivity and chronic hypoxic pulmonary hypertension in rats
- VernacularTitle:不同食用油对大鼠肺血管反应性和慢性低氧性肺动脉高压的影响
- Author:
Chuanyi LU
;
Dixun WANG
- Publication Type:Journal Article
- Keywords:
Oils;
Hypoxia;
Pulmonary artery
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of dietary oils on pulmonary vasoreactivity and chronic hypoxic pulmonary hypertension were assessed in rats fed on soybean oil, pig oil, soybean oil plus pig oil or regular diets for two months before the start of normobaric hypoxia(10?0.5%O_2 ventilation, 8 hours per day, 14 days). Mean pulmonary arterial pressures and pulmonary vasoreactivity to acute hypoxia were higher in the chronically hypoxic rats fed on 15% soybean oil than in the rats fed on 15% pig oil, 7.50% soybean oil plus 7.5% pig oil or regular diets. Hypertrophy of the right ventricle in the rats fed on 15% soybean oil were more serious as well. Blood viscosity and hematocrit were not different among the four groups of chronic hypoxia. The findings suggest that dietary soybean oil can potentiate hypoxic pulmonary vasoconstriction, and thereby promote the development of pulmonary hypertension and right ventricular hypertrophy.
