Changes of cyclic AMP and adenylate cyclase activity in different brain areas of rats during aseptic fever
- VernacularTitle:大鼠无菌性炎症发热时不同脑区cAMP含量和腺苷酸环化酶活性的变化
- Author:
Dejun XING
;
Kuiqin DU
- Publication Type:Journal Article
- Keywords:
Fever;
Inflammation;
Adenosine cyclic monophosphate;
Adenyl cyclase
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Fourty rats were divided into four groups and the aseptic inflammation was induced by subcutaneous injection of cronton oil into the back of 30 rats. Body temperature were gradually rose up after injection. The highest temperature appeared on the second day, then run down in the following days, and went back to normal on the eighth day. Brain were dissected in 10 normal rats without fever(group 1), other 10 rats at the peak of fever(group 2), and another 10 rats in the recovery phase on the third day (group 3). Ten rats in group 4 were used for observing the whole process of temperature change from injection day to the eighth day without brain dissection. The results showed that at the peak of fever, the levels of both cAMP and AC activities in hypo. thalamus were increased (P
