Effect of Naloxone on changes of cardiac function and its mechanism after acute coronary occlusion in rabbits
- VernacularTitle:纳洛酮对急性冠脉闭塞后家兔心功能的影响及其机制的研究
- Author:
Dandan ZHAO
;
Jimao WU
- Publication Type:Journal Article
- Keywords:
Naloxone;
Propranolol;
Myocardial infarction
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of the opiate receptor antagonist naloxone on myocardial contractility and relaxation after acute coronary occlusion in rabbits and the relationship between its effect and ?-adrenergie receptor were observed. The results showed that during the early stage of acute coronary occlusion myocardial contractility and relaxation were significantly increased and cardiac function was improved by naloxone; The action of naloxone can be abolised by ?-adrenergic receptor blocker propranolol. These results indicated that there was a close correlation between the action of naloxone on myocardial contractility and relaxation and the adrenergic nerve activity.
