Effect of insulin on the expression of HLA class Ⅱ antigens and antigen-presenting function of normal human monocytes
- VernacularTitle:胰岛素对人单核细胞HLAⅡ类抗原表达和抗原提呈能力的影响
- Author:
Shiquan XIONG
;
Xinwei FENG
- Publication Type:Journal Article
- Keywords:
Monocytes;
Insulin;
HLA antigens
- From:Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Insulin has been found to enhance specific immune function in experimental animals. However, it remains hitherto unnoticed whether the antigen-presenting capability and expression of Ia antigens of the macrophage, known to be essential for the induction of both cell-mediated immunity and humoral immune response to most antigens, could also be influenced by insulin. In the present study, it was demonstrated that insulin, in a concentration of 1.03?10~(-7) mol/L, promoted the antigen-presenting capability of human monocytes significantly. Furthermore, we found that the expression of HLADQ antigen on monocytes was markedly enhanced by insulin while that of HLA-DR determinant was not affected significantly. We suggested, therefore, that the promotion of antigen-presenting capability of human monocytes by insulin may be attributed, at least in part, to its enhancing effect on the expression of HLA-DQ antigen on the monocytes.
