Production model of focal cerebral ischemia and adenylic acid,calcium and MDA changes following focal cerebral ischemia in tupaiidae
- VernacularTitle:树鼩局部脑缺血模型的复制及缺血后腺苷酸、钙和MDA等的变化
- Author:
Yeu TAN
;
Zican WANG
- Publication Type:Journal Article
- Keywords:
Tupaiidea;
Cerebral ischemia;
Adenylic acid;
Lipoperoxide;
Calcium
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Tupaiidae has been considered as low primate by most scholars. Focal cerebral ischemia study on tupaiidae has not been reported. Acute focal cerebral ischemic model in tupaiidae was produced by cauterizing the middle cerebral artery. The results indicated that after 15 minutes and 6 hrs occlusion of the middle cerebral artery, the rCBF's in the ischemic cortex were reduced respectively to 36.7% and 39.8% of those before occlusion, and the amplitudes of SFP to 21.83% and 36.78%. After 6 hrs of ischemia, a decrease in ATP content to 5.2 times that of the control, and an increase in AMP to 4.4 times were measured. Calcium and MDA contents in ischemic cerebral cortex increased (P
