AN EXPERIMENTAL MODEL OF CEREBRAL CONCUSSION GUINEA, PIG AND THE MORPHOLOGICAL CHANGES
- VernacularTitle:豚鼠脑震荡实验模型的建立和形态观察
- Author:
Fengsheng YAO
- Publication Type:Journal Article
- Keywords:
Cerebral concussion Experimantal animals model of cerebral concussion Morphological change
- From:
Chinese Journal of Forensic Medicine
1986;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
An experimental model of cerebral concussion induced by blunt force stroke in 46 guinea pigs was established. 30 out of 46 animals were unconscious immediately after stroke followed by recovery Within few minutes without any seuqel in the posttraumatic period The animals were killed at 3,6,12,24,48 and 72 hours, 1,2,3,4 weeks after injury. Within 72 hours after injury, some of axons of both the afferent and the efferent nerve fibers of the corpus callosum and the brain stem were swelling like necklace or disrupted into segments macrophage infiltration, glosis, satellitosis, pyknosis of nuclioli of neuron, lysis of nissles bodies, vascular reaction as well as the retraction of the torn ends of axon as demonstrated by the silver stain were observed in animals killed 24 and 48 hours after injury. The reaction mentioned above became milder and milder 1～4 weeks after injury. Brain contusion were produced in other 16 experimental animals. In 7 animals of control group, no change was observed
