Toxicological and General Pharmacological Studies of Coleus forskohlii Oral Solution
- VernacularTitle:毛喉鞘蕊花口服液毒理学及一般药理研究
- Author:
Xinhua WANG
- Publication Type:Journal Article
- Keywords:
Coleus forskohlii;
Oral solution;
Mice;
Acutetoxicity;
Rats;
Subchronic toxicity;
Rabbits;
General pharmacologic effects
- From:
Journal of Kunming Medical University
1989;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Coleus forskohlii oral solution is a composite preparation containing several effective constituents of the plant, such as isoforskolin, 1-acetylforskolin etc.Following ig administration of the oral solution equivalent to≤35 g (raw herb)/kg to mice, neither toxic reaction nor death was observed. After the oral solution 30, 15, 10 g/(kg?d)?60 ig to rats, their appearance, body weight, and hematological, biochemical and pathological investigations were basically normal. In anesthetized rabbits intraduodenally administered the oral solution≤10g/kg, the respiration, airway secretion, blood pressure, ECG and EEG did not change significantly.These results indicate that Coleus forskohlii oral solution is a quite safe preparation.
