The calcium antagonism of hegan-zhupi decoction——Effects of HZD,magneseium ion and diltiazem on cultured rat liver cells injured by CCl_4
- VernacularTitle:和肝助脾饮和镁离子以及硫氮唑酮对初代培养大鼠肝细胞四氯化碳损伤的影响
- Author:
Wenzhong XU
;
Qifu HUANG
- Publication Type:Journal Article
- Keywords:
Calcium channel blockers;
Cells,cultured;
Medicine, Chinese traditional
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The protecting effects of HZD, DZ and Mg~(2+) on isolated cultured rat li ver cells injured by CCl_4 was compared in this article. The results showed that HZD (15?l/ml)or DZ(10~(-4)M)or Mg~(2+)(4.8?10~(-3)M)added to the liquid culture of rat liver cells, inhibited the overloading of calcium ions and the leakage of LDH and GOT in hepatocytes effectively. The contents of Ca~(2+) ion were positively related to the leakage of enzymes.The intensity of inhibition effects to the calcium overloading and the enzyme leakage in HZD were situated between those in DZ and Mg~(2+).
