Effcts of the panaxadiol saponins on serum 5-HT and platelets in dog with hemorrhagic shock
- VernacularTitle:人参二醇组皂甙对失血性休克犬血清5-HT的影响及对血小板的保护作用
- Author:
Dan ZHAO
;
Xuejian ZHAO
- Publication Type:Journal Article
- Keywords:
Shock, hemorrhagic;
Ginseng;
Saponins;
5-Hydroxytryptamine
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Experiments were performed on 29 healthy mongrel dogs with average body weight of 13?2.2kg. The animals were randomly divided into three groups:(1) nine dogs in the hemorrhagic shock group(HS); (2) tendogs in the panaxadiol saponin pretreatement group (HSG), which were intravenously injected with 25mg panaxadiol saponin 1 h before bleeding; (3) In the dexamethasone pretreatment group, othet ten dogs were intramuscularly injected with 1 mg/kg body wt of dexamethasone 1 h before bleeding. The mean arterial pressure of 5.3 kPa was kept during experimental period. The morphological changes of platelet were observed with scanning electromicroscope. The results showed that the platelet damage was much lighter in HSP and HSD gnoups than that of the HS group. The seum 5-HT content of HS group gradually increased hemorrhage with time delay. In the HSG group,the 5-HT level was increased from 1 and 3 h after bleeding,then it was decreased at 4 and 5 h. In the HSD group 5-HT level didn′t show any change from prebleeding to postbleeding. However, in the HS group 5-HIAA concentration increased significantly from 3rd to 5th hour after bleeding in the HS group,but was not in the HSG and HSD groups. These findings suggest that the panaxadiol saponins and dexamethsone can effecti vely inhibit the increasing of 5-HT and 5-HIAA levels in the themorrhagic shock.
