Morphalogical and functional changes of HL-60 cell lines after induction of differentiation by notogenscnoside R_1
- VernacularTitle:三七皂甙R_1诱导HL-60细胞系分化的形态和功能变化
- Author:
Luolin XU
;
Qi WU
- Publication Type:Journal Article
- Keywords:
Leukemia;
cell Line;
cell differentiation
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
HL-60 cells treated with 80?g/ml notogensenosidc R_1, were induced to granulocytic differentiation to 68% (among which metamyelocytes 32%, banded neutrophils 30% & segmented neutrophils 6%). Further experiment showed that the ability of the cell to reduce nitroblue tetrazolium (NBT) dye, phagocytosis, as complement receptors and activities of acid phosphatase and ?-glucuronidase were all enhanced after differentiation. There were significant differences between the treated groupand the control group in NBT positive rate (62% v. s. 10%, P
