Effects of Ilexonin A on acute hypoxic pulmonary vasoconstriction in rats
- VernacularTitle:毛冬青甲素对大鼠急性缺氧性肺血管收缩反应的影响及其机制
- Author:
Ting XU
;
Xianrong JIN
- Publication Type:Journal Article
- Keywords:
Anoxia;
Vasoconstriction;
Prostaglandins;
Leukotrienes
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Acute hypoxic pulmonary vasoconstriction (HPV) plays an important role in physiological regulation. The purpose of this study was to explore the effects of Ilexonin A on hemodynamics and HPV, and their relation to prostaglandins (PG_(?)) and leukotrienes (LT_(?)).The results show that the high pulmonary vascular resistance induced by Ilexonin A in normoxic rats may be partially caused by the increased LTs and have no relation to PGs. Ilexonin A may potentiate HPV at least by two ways: replacing the production of PGs (especially PGI_2) in hypoxic Wistar rats, and increasing LTs production.
