Morphological effect of hypertonic sodium chloride on rabbit kidney with hypovolemic shock——ultrastractural observation
- VernacularTitle:高渗氯化钠对兔失血性休克时肾形态的影响——超微结构观察
- Author:
Youzhi SHAO
;
Guiyun LIU
- Publication Type:Journal Article
- Keywords:
Saline solution, hypertonic;
Shock;
Kidney;
Rabbits
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
In the present experiments, the effect of hypertonic NaCl infusion on the renal ultrastructure in rabbits with hypovolemia was examined by electron microscopy. Rabbits were anasthetized with pentobarbital sodium and submitted to control bleeding and held at a mean arterial pressure of 40 mm Hg for 45 minutes. They were then given 6 ml/kg i. v. of 1) isotonic NaCl (300 mosm/L; 2) hypertonic NaCl (2400mosm/L). Only animals receiving hypertonic NaCl had immediate and permanent resto ration of mean arterial pressure and nearly intact ultrastructure of nephron. However, the animals with isotonic NaCl had an ischemic changes of nephron ultrastructure and unrestored mean arterial pressure.
