Protective effect of taurine on rat's myocardial injury induced by isoproterenol
- VernacularTitle:牛磺酸对大鼠异丙肾上腺素心肌损伤的保护作用
- Author:
Yah YU
;
Jian TANG
- Publication Type:Journal Article
- Keywords:
Isoproterenol;
Calcium;
Angiotensin;
Taurine
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
On the model of myocardial damage induced by subcutaneous injection of isoproterenol (40mg/kg, twice) into rats, it was found that the myocardial calcium content and the level of myocardial angiotensin Ⅱ (AGT Ⅱ,ir) were significantly elevated, and that severe myocardial ischemic lesion occurred. The treatment with taurine (200mg/kg, twice) or captopril(1mg/kg, twice)antigonized the above effects of isoprotercnol dramatically and ameliorated the myocardial damage. The results suggest that taurine has inhibitary action on synthesis of heart AGT Ⅱ, and that this is one of the important mechanisms by which taurine protects heart from isoproterenol-induced myocardial injury.
