Changes of immune and neuroendocrine functions in neonatal thymectomized rats
- VernacularTitle:初生期去胸腺雄性大鼠免疫及神经内分泌功能的变化
- Author:
Shouliang GONG
;
Weihong LIU
- Publication Type:Journal Article
- Keywords:
Thymectomy;
Immunity;
Hypothlamo hypophyseal system
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The present study has demonstrated a lowered reactivity to Con A stimulation, and also a decreased IL-2 production by splenocytes in adult male rats which were thymectomized within 48 h after birth. Meantime, their body weights, pituitary and testicular weights, serum LH and FSH levels, serum and urine TS contents, and pituitary cAMP contents were all lower than that of the control. The hypothalamic 5-HT metabolism showed that a change of hypothalamic-pituitary-gonad axis might have occured after neonatal thymectomy in male rats.
