Effects of dietary magnesium on hypoxic pulmonary vasoconstriction and chronic hypoxic pulmonary hypertension in rats
- VernacularTitle:高镁饮食对大鼠缺氧性肺血管收缩反应和慢性缺氧性肺动脉高压的影响
- Author:
Chuan LU
- Publication Type:Journal Article
- Keywords:
Magnesium;
Hypoxia;
Lung, pulmonary hypertension
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
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Abstract:
The effects of dietary magnesium on pulmonary vascular reactivity and chronic hypoxic pulmonary hypertension were assessed in rats. The rats were fed on a high magnesium diet or a regular diet begining 8 weeks before the start of normobaric hypoxia (10?1.0% O_2 Ventilation, 8 hours per day, 14 days). The plasma level of magnesium Was significantly increased in the high magnesium group as compared to the control. Mean pulmonary arterial pressure, pulmonary vascular resistance and pulmonary vascular reactivity to hypoxia in the rats fed on high magnesium diet were markedly lower than that in the rats fed on regular diet. Hypertrophy of the right ventricle in the rats fed on high magnesium diet were significantly lower as well. Blood viscosity and hematocrit had no difference between the high magnesium group and the control. These findings suggested that dietary magnesium can attenuate basic pulmonary vascular resistance and hypoxic pulmonary vasoconstriction, and therefore can prevent the development of chronic hypoxic pulmonary hypertension and right ventricular hypertrophy.
