Effects of total glucosides of paeony(TGP) on immune system
- VernacularTitle:白芍总甙对免疫系统的影响
- Author:
Xingwang WANG
- Publication Type:Journal Article
- Keywords:
Immunity;
Antibodies;
Lymphocytes
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The hemolysin (IgM) production by mouse splenic lymphocytes immunized with sheep red blood cell in vitro was enhanced by lower concentrations (0.1-0.4?g/ml) of total glucosidcs of pacony (TGP), but diminished by higher concentrations (0.4-3.2?g/ml) of the drug. The dual effects of TGP on ConA induoed proliferation of mouse splenocytcs was also observed by in vitro treatment with TGP over a range of 0.05-1.6?g/ml. These results suggested that effects of TGP on immune system was definitely depend on the concentrations of TGP administered.The specific helper T (Th) cclls were induced by irradiation with ~(60)Co at 800R plus primed thymocytes and were measured by the adoptiver transfer system. It was found that the higher generation of Th cells incroosed further by TGP (5mg/kg, ip).
