Influence of LTC_4 on the microcirculation of the gastric mucosa and its effect on acute gastric mucosal injury
- VernacularTitle:白三烯C_4对大鼠胃粘膜微循环的影响及其在急性胃粘膜损伤中的作用
- Author:
Heqian LI
;
Ye CHUAN
- Publication Type:Journal Article
- Keywords:
SRS-A;
Microcirculation
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The author explored the influence of exogenous LTC_4 (0.1 ng. 100g~(-1),iv) on the microcirculation of gastric mucosa and its effect on acute gestric mucosal injury. Male Wistar rats underwent a fast of 24 hours before the experiment and could drink water freely during this period. The results showed: 1. The caliber of the gastric mucosal superficial capillaries thinned and part of the capillaries disappeared. The caliber of collecting venule thinned also. After 10 minutes there were remarkable venous stasis and heamorrhage. 2. It was confirmed by the method of hydrogen clearence that the gastric mucosal flow reduced significantly. After 15 minutes of the injection, it decreased from original 1.230?0.093 to 0.521?0.079 ((?)+SE) ml, min~(-1). 100g~(-1) (P
