The effects of sodium salicylate on febrile response and changes of cAMP and PGE_2 level in c. s. f, after intraventricular perfusion of EGTA in rabbits
- VernacularTitle:家兔静脉灌注水杨酸钠对EGTA性发热及其脑脊液cAMP,PGE_2含量的影响
- Author:
Daan WANG
;
Chujie LI
- Publication Type:Journal Article
- Keywords:
Fever;
Sodium;
Calcium;
Adenosine cyclic monophosphate;
Prostaglandins E
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to determine further whether cAMP and PGE takes part in the mechanism of EGTA-induced fever in the present experiment with 40 New Zealand rab bits, the influence of intravenous infusion of sodium salicylate (SS) on the febrile response and the rise of cAMP and PGE_2 concentration in c.s.f. produced by intraventricular perfusion of EGTA were observed. The results showed that intravenous infusion of SS (9.6?M/min. following an initial dose of 1.25mM) could inhibit the rise of PGE_2 concentration in c.s.f. (P0.05) after 0.6 mM EGTA was perfused into lateral cerebroventricle. The concentration of cAMP in c.s.f. was correlated apparently positively with the febrile response in EGTA-induced fever (r=0.9839, P
