The inhibitory effect of 3', 5'-cCMP on the production of human interleukin-2 and the expression of interleukin-2 receptors in vitro
- VernacularTitle:胞苷环3’,5’一磷酸对正常人淋巴细胞分泌IL-2和IL-2受体表达的抑制作用
- Author:
Mingchun WANG
;
Yangqiu LI
- Publication Type:Journal Article
- Keywords:
Cytidine cyclic monophosphate;
Interleukin Ⅱ;
Receptor;
Cell line
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
0.2mM Cytidine 3', 5'-monophosphate (3', 5'-cCMP) inhibits not only the IL-2 production of human peripheral blood mononuclear cells (PBMC) but also the expression of IL-2 receptors. The inhibitory rate on expression of IL-2 receptors is 28.9+1.9%. The proliferation of CTLL-2 cells can be stimulated by 3', 5'-cCMP in concentration from 0.00625mM to 0.2mM when the presence of IL-2 is sufficient. The stimulative effect in low concentration of 3', 5'-cCMP is more obvious than that in high concentration.
