Studies on the pathogenesis of renal insufficiency in acute hepatic failure
- VernacularTitle:急性肝衰竭时肾功能障碍发生机理的探讨
- Author:
Rui WANG
;
Xianming CHEN
- Publication Type:Journal Article
- Keywords:
Endotoxins;
Liver diseases;
Kidney failure, acute
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The experiments were designed to study the relation between endotoxamia and renal insufficiency and the protective effects of RSM on galactosamine-induced acute hepatic failure. The results indicated that galactosamine-treated rats which all accompanied with endotoxamia exhibited significant renal dysfunction (Per, BUN elevated; UV, Ccr, U_(Na)V fell; FE_(H2O), FE_(Na) enhanced). After treatment of RSM, the endotoxemia was reduced while renal functions were improved. It suggested that there was a close relationship between endotoxemia and renal insufficiency. The experiment proved that the endotoxin was an important factor in the occurance and development of HRS. RSM possessed marked preventive and theraputic effects for HRS. In addition, the model of galactosamine-induced hepatic failure could be used to study the pathogenesis, prevention and therapy of HRS simultaneously.
