Protective effect of chlorpnomazine on ischemic heart of rats and its mechanisms
- VernacularTitle:氯丙嗪对大鼠缺血性心脏的保护作用及其机制探讨
- Author:
Bing SHI
;
Xing LU
- Publication Type:Journal Article
- Keywords:
Chlorpromazine;
Myocardial diseases;
Free radicals;
Lipid peroxides;
Stress
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Protective effects of chlorpromazine on ischemic heart and its mechanisms were investigated in rats with acute myocardial infarction (MI). 30 SD female rats were divided into three groups. the ischemia group, being subjected MI by coronary ligation, the MI+chlorpromazine group and the control. All samples were taken at 2 hours after operation. The ischemia group, as compared to the control, showed remarkable ultrastructural damage in ischemic myocardium and significant increases in serum CPKmb by 77%, serum cortisol by 67% and serum malondialdehyde (MDA) by 25%(P
