Inhibitory effect of Tau on the fever induced by ET and EGTA
- VernacularTitle:牛磺酸对ET和EGTA性发热的降热效应
- Author:
Chaofeng HU
;
Chujie LI
- Publication Type:Journal Article
- Keywords:
Fever;
Taurine;
Endotoxin
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
40 New Zealand white rabbits were used to observe the effect on the fever caused by ET (endotoxin) and EGTA [ethylene glycol bis-(?-aminoethylethylether)-N, N, N′, N′-tetraacetic acid] after ICV (intracerebroventricular) infusion of Tau and CaCl_2 into rabbits. The results showed that Tau ICV perfusion could inhibit the initial febrile response to ET and EGTA in rabbits (P0.05), which could be blocked by ICV infusion of CaCl_2. The authors suggested that Tau might increase the level of Ca~(++) in the hypothalamus and reduce Na~+/Ca~(++) ratio, then lower the fever.
