Study of reactivity of pulmonary vessel on chronic hypoxic rats in different strains
- VernacularTitle:不同种系慢性缺氧大鼠肺血管反应性的研究
- Author:
Ming FAN
;
Dixun WANG
- Publication Type:Journal Article
- Keywords:
Anoxia;
Leukotrienes;
Prostaglandins
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of diethylcarbamazine (DEC), an inhibitor of leukotrienes (LTS) synthesis or indomethacin, an inhibitor of prostaglandins (PGs) synthesis was investigated in chronic hypoxic pulmonary hypertension and reactivity of pulmonary vessels in different strains of rats. The results showed that in Wistar rats, DEC could prevent chronic hypoxic pulmonary hypertension and right ventricular hypertrophy. (?)pa and PVR were reduced, (?)pa from 3.2?0.04kPa to 2.4?0.05kPa; PVR from 76271?3274 dyno?s?cm~(-5) to 35948?3182 dyn?s?cm~(-5) respectively (P
