Therapeutic Effects of Complex Nucleosides from Chinese Medicine on Two Experimental Models of Heart Failure
- VernacularTitle:心脉龙对两种实验性心脏疾病模型的治疗作用
- Author:
Yuehua HUANG
- Publication Type:Journal Article
- Keywords:
Complex nueleosides;
Experimental myocardial infarction Acute experimental heart failure
- From:
Journal of Kunming Medical University
1990;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Therapeutic effects of complex nucleosides were studied by using two models of heart failure caused by either the ligation of the anterior interventricular branch of the coronary ar- tery in anesthetized dogs or iv injection of a mixed solution of verapamil and propranolol (0.5mg/Kg respectively)in anesthetized rats.After iv complex uncleosides 0.5mg/Kg/min for 10 min in the dogs and 5 mg/Kg/min for 4 min in the rats,a positive inotropic effect and an increase of cardiac output were observed,but no influence on the peripheral resistance,myocardial oxygen consumption and heart rate.Complex nucleosides had no effect on the S-T segment elevation due to the myocardial ischemic injury.On a rat model of verapamil and propranolol-induced heart failure dopamine 2 mg/Kg iv showed cardiovascular effects,which is similar to complex nucleosides.
