Studies on anti-lipid peroxidative injury effect of tetramethylpyrazine on experimental membranous glomerulonephritis in rabbits
- VernacularTitle:川芎嗪抗实验性膜性肾炎脂质过氧化损伤的研究
- Author:
Lingqun ZHU
;
Qifu HUANG
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis;
Lipid peroxides;
Superoxide dismutase;
Glutathione peroxidase;
Rabbits
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Experimental membranous glomerulonephritis(MGN) in Japanese white rabbits was induced by administration of C-BSA according to Border's method. The results showed that the lipid peroxides(LPO) content in plasma and renal cortex were significantly increased compared with that in the controls. On the other hand, the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-px) in whole blood and renal cortex were significantly reduced compared with that in the controls. The results suggested that experimental MGN existed a mechanism of cellular injury manifested as lipid peroxidation in biomembrane, and such injury might be related to toxic effects of reactive oxygen on biomembrane. Tetramethylpyrazine was used to treat experimental MON. The results showed that the drug might have reduced the amount of proteinuria and the extent of lipid peroxidative injury. At the same time, the drug might haod raised the activities of SOD and GSH-px, and improved the lesion ot some extent. It is suggested that tetramethylpyrazine had the effect of anti-lipid peroxidative injury.
