Effects of cigarette smoking on hemodynamics and hypoxic pulmonary vasoconstriction in rats: role of prostaglandins and leukotrienes
- VernacularTitle:吸烟对大鼠血流动力学及缺氧性肺血管收缩反应的影响:前列腺素与白三烯的作用
- Author:
Gang CHEN
;
Dixun WANG
- Publication Type:Journal Article
- Keywords:
Anoxia;
Pulmonary circulation;
Prostaglandins X;
Thromboxanes;
Smoking
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The changes of hemodynamics and hypoxic pulmonary vasoconstriction (HPV) inducedby cigarette smoking and the role of prostaglandins(PGs) and leukotrienes (LTs) were studied in rats. During smoking, systemic and pulmonary vascular resistance (SVR and PVR) increased 47% and 39%, respectively. The level of TXB_2 rose by 144% in plasma and 69% in lung tissue. HPV increased two-fold after smoking (△PVR increased from 55% to 102%). LTs receptor antagonist, LY-171883, prevented the smoking-in duced increase of SVR and PVR and augmentation of HPV. Cyclooxygenase inhibitor, in domethacin, prevented partly increase of PVR but not HPV induced by smoking. Our results suggest that smoking leads to pulmonary and systemic vasoconstriction and augmentation of HPV mediated by LTs, the increase of PVR during smoking is also mediated by TXA_2, This study also found that LY-171883 inhibited HPV by 72%, the result indictates that LTs mediate HPV in Wistar rats.
