Experimental study of fibrinolytic activation-effect of catecholamines on fibrinolytic activity
- VernacularTitle:纤溶系统激活的实验研究—儿茶酚胺对纤溶活性的影响
- Author:
Guangjin ZHU
;
Chaofeng ZHOU
- Publication Type:Journal Article
- Keywords:
Plasminogen activators;
Propranolol;
Phentolamine Catecholamines
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The present study, using the different catecholamines, observed the effects on plasminogen activator (PA) activity release in the vascular wall of rat hindlegs. The results showed that adrenaline perfusion induced the highest PA activity in three different catecholamines. Propranolol completely blocked PA activity induced by isoprenaline. PA activity induced by adrenaline or noradrenaline was completely inhibited by propranolol combined with phentolamine. During physiological stress the increase of plasma noradrenaline level was accompanied with higher PA activity. These data indicated that exogenous catecholamines produced a increase of PA activity via ?-adrenoreceptors stimulation mainly, as well as ?-receptors partially. The endogenous increase of catecholamines showed the same effect on fibrinolytie system.
