Effect of liooxygenase and cyclooxygenase blockade on acute hypoxic pulmonary vasoconstriction in yunan monkey
- VernacularTitle:环氧合酶及脂氧合酶抑制剂对猕猴急性肺泡缺氧性肺血管收缩反应的研究
- Author:
Aiping ZOU
;
Gang CHEN
- Publication Type:Journal Article
- Keywords:
Anoxia;
Prostaglandins;
Arachidonic acids
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The hypoxic pulmonary vasoconstriction (HPV) in Yunan monkey has been observed. The results showed that acute alveolar hypoxia caused significant pulmonary hypertension, associated w~th art increase in pulmonary vascular resistance. The maximal response appeared 3 min after onset of hypoxia. Monkey may be proposed as moderate responder in HPV. The HPV in monkey was blocked by lipoxygenase inhibitor diethylcarbamazine and enhanced by cyclooxy genase blocker...indomethacin. It is suggested that lipoxygenase metabolites leukotrienes probably play the role of a mediator in HPV of monkey, whereas cyclooxygenase metabolites prostaglan dins act as medulator.
