The changes of calmodulin and cAMP in rabbit myocardium during ischemia and reperfusion
- VernacularTitle:心肌缺血及再灌注后心肌钙调蛋白及环磷酸腺苷含量的变化
- Author:
Hong XING
;
Xiaoming WANG
- Publication Type:Journal Article
- Keywords:
Calmodulin;
Adenosine cyclic monophosphate;
Heart
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
This study was performed on rabbits to examine the changes of calmodulin (CAM) and cAMP in the myocardium during ischemia and reperfusion by radioimmunoassay method. The result showed the levels of CaM and cAMP increased at 20 min of ischemia. Although these two parmeters were unchanged at 40 min of ischemia as compared with the changes at 20 min, they were changed during reperfusion at different times of ischemia. At 20 min ischemia following 10 min reperfusion, the content of CaM decreased, the content of cAMP increased. On the basis of 40 min ischemia, reperfusion induced opposite changes: CaM increased, cAMP decreased. The possible mechanism of these changes was discussed.
