The effect of DS-182 on mitochondrial changes induced by rat myocardial ischemia/reperfusion injury and its protective mechanism
- VernacularTitle:丹参素对大鼠心肌缺血/再灌注致线粒体变化的影响及其作用机理的探讨
- Author:
Li ZHANG
;
Xiaoming WANG
- Publication Type:Journal Article
- Keywords:
Mttochondrla;
Heart;
Myocardium;
Lipid peroxide
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The membrane fluidity of mitochondria isolated from langendorff perfused rat hearts was studied with ESR spin labeling technique and TBA method was used to detect the content of lipid peroxide. After total ischemia for 40min followed by a 20min reperfusion the 10-DSA region of the mitochondrial membrane showed significantly increased S (0.1(?)2?0.006) and ?_c(7.13?0.09?10~(10)sec) values (i. e. a decrease of membrane fluidity)in comparison with aerobic control (S=0.103?0.007); ?_c=6.86?0.20?10~(-10) sec) (P0.05). In addition, we found that DS182 could remove O_2~? produced by O_2~? generating system. Our results have showed that DS-182 is a potent scavenger of superoxide. The protective effect of DS-182 on mitochondria during ischemia/reperfusion might be due to its antioxidative activity。
