Comparative studies on mechanisms of endotoxin and prostaglandin E fever limit in rabbits
- VernacularTitle:家兔内毒素热限和前列腺素E热限成因的比较研究
- Author:
Chaofeng HU
;
Chujie LI
- Publication Type:Journal Article
- Keywords:
Fever;
Endotoxins;
Prostaglandins E;
Adenosine cyclic monophospate
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05) after non-fever limit (non-FL) dose and FL dose endotoxin (ET) was intravenously injected into rabbits. The increase of PGE_2 in CSF was not limited during the occurrence of ET FL. 2. Intracerebroventricular injection (ICV) of different dose of PGE_2 into rabbits induced dose-dependent fever, but there was no more rise in body temperature when the febrile response had reached a certain height. This is termed "PGE FL". 3. The concentration of cyclic adenosine-3′, 5′-monophosphate (cAMP)in CSF paralleled the fluctuation of temperature (r=0.9906, P
