An experimental study on the role of free radicals in the injury of renal ischemia and reperfusion
- VernacularTitle:自由基在肾缺血再灌流损伤中作用的实验研究
- Author:
Yungqing WANG
;
Yaping SUN
- Publication Type:Journal Article
- Keywords:
Free radicals;
Supero xide dismutase;
Allopurinol;
Kidney disease
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
In this experiment, it took the rat renal ischemic model with right nephrectomy and occlusion of the left renal pedical for 60 minutes. The effects of ischemia, reperfusion, allopurinol (AP) and superoxide dismutase(SOD) on this ischemic model were observed. The changes of serum creatine(Scr), renal coefficient(RC) and renal morphology were studied. In the reperfusion group which had sufferred from 60 minutes ischemia followed by 24 hours reperfusion, the Scr level was much higher than that in the pure isehemic group(P
