Studies on mechanism of myocardial injury induced by adrenergic alpha receptors and catecholamines
- VernacularTitle:?受体和儿茶酚胺所致心肌损害发生机理关系的实验研究
- Author:
Jun HUANG
;
Wenzhu MA
- Publication Type:Journal Article
- Keywords:
Norepinephrine;
Receptors adrenergic alpha;
Receptors, adrenergic beta;
Catecholamines;
Glycolysis
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Seventy eight New Zealand rabbits were divided into 8 groups. NE, M, and control group were given norepinephrine (1mg/kg), methoxamine or saline, respectively. The other 5 groups were given regitine (R group), propranolol (P group), metaprolol (MP group), yohimbine (Y group) and prazosine (PR group) respectively before NE infusion.Myocardial injury was estimated with a semi-quantitative histological scoring system, and 11 intermediate metabolites in glycolysis and ATP, ADP, AMP, CP in myocardium were measured. Results showed that myocardial injury was observed in NE group (P
