Assessment of the Effect of L-hydrochloro LYSINE on Growth and Development and Its Side-Fffect on Liver and kidney in Rats
- VernacularTitle:L—盐酸赖氨酸对大白鼠生长发育及肝、肾毒性作用的初步观察
- Author:
Zhu YUAN
- Publication Type:Journal Article
- Keywords:
L-hydrochloro lysine;
Toxic action;
Rats
- From:
Journal of Kunming Medical University
1988;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
A 28 days growth and development experiment and a 90 days intoxication experiment with —hydrochloro lysine at various dosage levels on young and adult rats were reported.The results were as follows. There were definitely an accelerating effect on growth and development in young rats when adding 0.5% L-lysine to a cereal diet, but no obviously similar effect in adult rats; moreover, a massive dose of L—lysine could induce hepatic and renal damage. The hepatic lesions were focal necrosis and increase of fat—storing cells with collagen fiber formation. In the kidney there were cloudy swelling, microvilli losing, intracellular edema, mitochondrial swelling, endopl asmic reticulum dilatation and residual body formation in the proximal convoluted tubule epithelium.
