Effect of hypoxia on rabbit lung surface tension-surface area and pressure-volume-hysteresis
- VernacularTitle:缺氧对家兔肺表面张力—表面积和压力—容量关系的影响
- Author:
Haiyun CHENG
;
Zhaoyun YIN
- Publication Type:Journal Article
- Keywords:
Tidal volume;
Surface tension;
Lung compliance
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The influence of acute and intermittent hypoxia on respiratory mechanics in the range of tidal volume of adult rabbits was studied. All is based on the assumption that the tissue structure of lung constitutes a conservative mechanical system and hence that pressure(P)-volume(V)hysteresis is primarily a result of surface tension(r)-surface area(s)hysteresis. It was found that the lung compliance of rabbits to acute hypoxia was decreased and respiratory work increased. Compared to control group (3.5?1.1mm),the working limbs of P-V loops of acute hypoxic rabbits increased by 49% (5.2?0.6mm). Such changes could be corrected in part by appropriate intermittent hypoxia, the length of working limbs of 5-day adaptation rabbits was 4.2?1.1(P
