The study of the possible correlation between the MDA and adenylate cyclase or cAMP of Ehrlich's ascites cancer
- VernacularTitle:小鼠艾氏腹水癌血清MDA与癌细胞腺苷酸环化酶及cAMP变化的相关研究
- Author:
Huiling YANG
;
Zhihan JIAN
- Publication Type:Journal Article
- Keywords:
Carcinoma, Ehrlich tumor;
Free radicals;
Adenosine cyclic monophosphate
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Ehrlich's ascites cancer (EAC) in BALB/C mice by ip transplantable EAC cell is reproduced by us. The change of serum malondialdehyde(MDA), plasma cellular cAMP and adenylate cyclase (AC) are examined in the early, middle and late phase of mice bearing EAC respectively in comparison with that of control group. Results indicate that serum MDA in mice bearing EAC is continuously increased with the progress of the disease in the remarked ways in comparison with the control group. Whereas the plasma cAMP in the mice bearing EAC is markedly decreased in that order. Relation between the change of serum MDA and the cellular cAMP, AC or plasma cAMP shows a significant negative correlation efficiency (P
