Reduction of myocardial postisehemic reperfusion injury with superoxide dismutase
- VernacularTitle:超氧化物歧化酶在心肌再灌注性损伤中的作用
- Author:
Hong LI
;
Yijing WU
- Publication Type:Journal Article
- Keywords:
Myocardium;
Ischemia;
Perfusion, regional;
Superoxide dismutase
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Activated oxygen has been proposed to play a role in postischemic cardiac damage. This is supported further by the ability of activated oxygen scavengers to limit myocardial reperfusion injury. This experiment was performed to determine if superoxide dismutase (SOD) infused starting with reperfusion has a beneficial effect on reperfused myocardiun?The isolated perfused rat hearts were subjected to ischemia followed by reperfusion for 45 min. Reperfusion damage was detected by occurrence of ventricular fibrillation, increase production of malondialdehyde, the release of lactate dehydrogenase and the reduction of sarcolemmal ATPase. The extent of reperfusion myocardial injury was significantly less in SOD treated group indicated by the indics mentioned above. The results of this study are in accord with previous concepts that activated oxygen plays a fundamental role in cellular damage resulted from reperfusion. In addition, we demonstrate that the administration of SOD begining at the onset of reperfusion can still be effective, it might be applicable to clinical case.
