Expression of the antigen detected by the monoclonal antibody AU_(14-1) in human cervical lesions
- VernacularTitle:单克隆抗体AU_(14-1)测定的抗原在人宫颈病变中的表达
- Author:
Gansheng WEN
;
Suyun WU
- Publication Type:Journal Article
- Keywords:
Antibodies, monoclonal;
Cervix neoplasms;
Antigens;
Immunochemistry
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
In this article, monoclonal antibody to mouse uterine cervical carcinoma (U_(14)), AU_(14-1), was used for immunohistochemical analysis of premalignant and malignant lesions of the cervix to investigate the incidence and significance of the expression of the antigen detected by AU_(14-1) in human cervical lesions. Peroxidase-antiperoxidase (PAP) staining was performed on formalin-fixed, paraffin-embedded biopsy specimens. It was reported that positive staining with AU_(14-1) was detected in 20 of the 20 squamous cell carcinomas, 13 of the 13 adenocarcinomas, 15 of the 21 carcinomas in situ, 2 of the 24 anaplasia, and 2 of the 20 chronic cervicitis. It is suggested that the expression of the U_(14) antigen may be related to malignant transformation in the cervix.
