The release of endogenous norepinephrine in the postischemic reperfused myocardium in the rabbits
- VernacularTitle:心肌缺血—再灌注损伤与心肌去甲肾上腺素的释放
- Author:
Wei AN
;
Anyun SHI
- Publication Type:Journal Article
- Keywords:
Perfusion;
Norepinephrine;
Calcium
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Various studies have suggested that adrcnergic activtaion may contribute to deleterious effects on myocardial ischemia. However, very little is known about it s role during reperfusion. This study was designed to explore the relationship between endogenous norepinephrine (NE) and reperfusion injury in intact rabbits. In rabbits(n=5) 35 min of coronary occlusion without reperfusion thc myocardial NE content of the ischemic area was not significantly different from that of the non-ischemic area, nor was tissue calcium content in both areas, while, in 35 min of occlusion followed by 10 min of reperfusion group(n=5), the tissue NE was markedly reduced in reperfused area accompanying significant calcium overloading. These studies suggest that the postischemic reperfusion injury may be, in part, due to endogenous catecholamine release during reperfusion.
