Effect of Bupleurum Chinense injection on endogenous pyrogen fever and change of cAMP concentration in cerebrospinal fluid in rabbits
- VernacularTitle:柴胡注射液对家兔内生致热原性发热及其脑脊液cAMP含量变化的效应
- Author:
Dao LI
;
Zhiqiang LIU
- Publication Type:Journal Article
- Keywords:
Fever;
Pyrogens;
Adenosine cyclic monophosphate
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The experiments were divided into two parts. The first part: inhibitory effect of Bupleurum Chinense injection on fever was observed. The second part: while Bupleurum Chinense injection inhibited fever, the cAMP concentration in cerebrospinal fluid was observed. The experimental fever models were induced by endogenous pyrogen from monocytes of rabbits' blood. The results obtained demonstrated that the Bupleurum Chinense injection (250mg/kg) had marked inhibitory effect on the endogenous pyrogen fever and the cerebrospinal fluid cAMP levels of the experimental group was obviously lower than in control. The authors inferred that inhibitory effect of Bupleurum Chinense injection on endogenous pyrogen fever may be obtained through some-link to reduced central cAMP content.
