Roles of leukocytes and oxygen free radicals in activated-complement-induced lung injury
- VernacularTitle:白细胞及其释放的氧自由基在活化补体导致急性肺损伤中的作用
- Author:
Hong ZHAO
;
Bingyong SUN
- Publication Type:Journal Article
- Keywords:
Leukopenia;
Lipid peroxides;
Superoxide dismutase;
Glutathionc peroxidase
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of zymosan-activated plasma(ZAP) on the lipid peroxides(LPO) content, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) in lung lymph and their relationship to lung injury were studied in control (with normal leukocyte count) and leukopenic goats. In the control goats, after ZAP infusion, LPO production elevated, that was coincided with the increase of lung lymph flow (QL), and the clearence rate of lung lymph protein (LLPC). SOD activity was also elevated, but GSHpx activity was inhibited. In leukopenic goats, ZAP challenge caused an increase in LPO production, but its content was lower than that in control goats. No marked change was observed in QL and LLPC. The results suggest that: (1) Leukocytes and oxygen free radicals are involved in the pathogenesis of lung injury due to ZAP infusion; (2) Leukocytes play an important role in producing oxygen free radicals.
