The kinetic alterations of plasma prekallikrein and antithrombin Ⅲ in rats following isoproterenol-induced myocardial infarction
- VernacularTitle:异丙肾上腺素性心肌梗塞血浆前激肽释放酶和抗凝血酶Ⅲ的动态变化
- Author:
Xuejun WANG
;
Chuanren DONG
- Publication Type:Journal Article
- Keywords:
Myocadial infarction;
Prekallikrein;
Antithrombin Ⅲ;
Isoproterenol;
Rats
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The kinetic alterations of plasma prekallikrcin(PKA) and antithrombin Ⅲ (AT-Ⅲ) following myocardial infarction induced by 2 injections subcutaneously of 85 mg isoproterenol/kg at 24 hours interval in rats were detected in this study, and the relationship between PKA, AT-Ⅲ and myocardial ischemia induced by isoproterenol were also discussed. It was found that the activity of PKA decreased significantly and AT-Ⅲ tended to decrease at 4 hours after the first injection of isoproterenol, both of the PKA and AT-Ⅲ at 24 hours were lower than those at 4 hours and evidently lower than those of normal control, and at 48 hours after the first injection of isoproterneol the PKA was still maintained at the same level of 24 hours but the AT-Ⅲ almost returned to the normal level.
