Effect of the culture supernatant of NPC cell line on cAMP、IL-2、and IL-2 receptor in lymphocytes
- VernacularTitle:鼻咽癌细胞培养上清对正常人淋巴细胞cAMP、IL-2及IL-2增殖活性的影响
- Author:
Zhihan JIAN
;
Xuening SHEN
- Publication Type:Journal Article
- Keywords:
Nasopharynseal neoplasms;
Immunosuppression;
Adenosine cyclic monophosphate
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
This paper reports on the effect of the culture supernatant of NPC cell line (CNE-2S) (400?l/ml) on cAMP、IL-2、and IL-2 receptor in normal lymphocyts. The cAMP levels of lymphocytes from 11 cases was 13.77?4.92pm/1?10~6. With lymphocytes suspensives added to the CNE-2S, the cAMP levels was increased to 26.1? 15.14Pm/1?10~6(P0.05)These results show that the immune function abnormality of the patients with NPC relates to the fact of that the NPC immunologic inhibitory factor declines the ability of lymphocytes to produce IL-2.
