Effect of alternariol monomethyl ether on the lipid peroxidation in the epithelia of fetal esophagus and stomach
- VernacularTitle:交链孢酚单甲醚对人胎儿食管和胃上皮脂质过氧化的影响
- Author:
Peng ZHANG
;
Ziming DONG
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Fungi;
Alternaria;
Carcinogens;
Lipid peroxides
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of Alternariol Monomethyl Ether (AME), a suspected carcinogen in human being, on the lipid peroxidation in the epithelia of fetal esophagus and stomach was studied. The epithelia of esophagus and stomach of human fetus induced labor with water-bag were treated with AME. Lipid peroxides were measured by thiobarbituric acid test for malondialdehyde (MDA). There was a positive correlation between the values of MDA levels and AME dosaeges. It demonstrated that the lipid peroxdation could be initiated with AME. Lipid peroxidation levels were increased following treatment time elongating. The values of MDA levels in esophagus were higher than those in stomach, which were treated with the same dosaege of AME. It showed that AME had an organ selectivity. These results indicate that AME may be one of genetoxic etiological factors of esophageal carcinoma in Linxian county.
