The effect of endotoxin, on prostaglandin production in macrophages and endothelial cells
- VernacularTitle:内毒素对巨噬细胞和内皮细胞前列腺素合成的影响
- Author:
Dianmo XIAO
- Publication Type:Journal Article
- Keywords:
Endotoxins;
prostaglandins;
Macrophages;
Endothelium
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The endotoxin stimulated immunoreactive PGI_2, PGF_(2?), PGE_2 and TXA_2 synthesis by mice resident peritoneal macrophages and bovine aorta endothelial cells. The stimulating effect depends on dose and time. The endotoxin also stimulated the release of [~3H] PGI_2 and [~3H] arachidonic acid from [~3H] araehidonic acid prelabelled endothelial cells. The endotoxin-stimulated prostaglandin production was inhibited by polymyxin B, cycloheximide and the antiinflammatory steroid, dexamethasone. Endotoxin might stimulate arachidonic acid metabolism by regulating liberation of esterified arachidonic acid from cellular lipids.
