The inhibitory effects of diethylcarbamazine citrate on hypoxic pulmonary vasoconstriction in dogs
- VernacularTitle:枸橼酸乙胺嗪对狗急性缺氧性肺血管收缩反应的抑制作用
- Author:
Shuren LI
- Publication Type:Journal Article
- Keywords:
Anoxia;
Hypertension;
Pulmonary wedge pressure;
Diethylcarbamazine;
SRS-A
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of diethylcarbamazine citrate (DEC), a lipooxygenase inhibitor, on hypoxic pulmonary vasoconstriction (HPV) in dogs were studied, The results showed that HPV was significantly inhibited after the intravenous administration of DEC, and that the inhibitory effect of DEC on HPV had seemingly no association with the decrease of systemic blood pressure and depression of cardiac function induced by DEC. It is suggested that leukotrienes play a role of mediator in HPV in dogs.
